Pills & Potions: The Evolution of Calcium Channel Antogonists

Table of Contents

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• OBJECTIVES
  
• OF PILLS AND POTIONS
  
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• INTRACELLULAR Ca++ FUNCTIONS
  
• Calcium Balance Chart
  
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• Cell Structure Chart
  
• PROPOSED THAT TWO CALCIUM CHANNELS EXIST
  
• RECEPTOR OPERATED CHANNEL
  
• VOLTAGE SENSITIVE CHANNEL
  
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• CALCIUM CHANNEL ANTAGONISTS
  
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• CALCIUM CHANNEL ANTAGONISTS
  
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• FIRST GENERATION CALCIUM CHANNEL ANTAGONISTS
  
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• SECOND GENERATION AGENTS
  
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• CONGESTIVE HEART FAILURE
  
• SECOND GENERATION CALCIUM CHANNEL ANTAGONISTS
  
• SECOND GENERATION AGENTS
  
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• TIGHT HYPERTENSIVE CONTROL
  
• TIGHT HYPERTENSIVE CONTROL
  
• THREE STUDIES REPORTING INCREASED RISK WITH ANTIHYPERTENSIVE DRUGS
  
• SECOND GENERATION AGENTS
  
• SECOND GENERATION AGENTS
  
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• DRUGS METABOLIZED BY CYP 3A3/4
  
• DRUGS INHIBITING
  
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• CALCIUM CHANNEL ANTAGONISTS
  
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• L-type Channel Model
  
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• Calcium Balance Chart
  
• Calcium Balance Chart
  
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• SECOND GENERATION AGENTS
  
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• FIRST GENERATION AGENTS

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